{"product_id":"cbetsplgahg","title":"Temperature-Sensitive PLGA-PEG-PLGA Hydrogel for Bioelectronics, 10 g\/bottle, CBETSPLGAHG","description":"\u003cp\u003eThe temperature-sensitive poly(lactic-co-glycolic acid)-poly(ethylene glycol)-poly(lactic-co-glycolic acid) (PLGA-PEG-PLGA) triblock copolymer hydrogel is an advanced, stimuli-responsive biomaterial. While historically celebrated for drug delivery and injectable tissue-engineering scaffolds, it is increasingly incorporated into bioelectronic interfaces—such as smart biosensors, flexible neural probes, and implantable electrophysiological electrodes—to bridge the mechanical and biological mismatch between rigid hardware and soft living tissue.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSol-to-Gel Transition (LCST-like Behavior)\u003c\/strong\u003e: At lower temperatures (e.g., room temperature or refrigeration, 4°C–10°C, aqueous solutions of PLGA-PEG-PLGA remain in a free-flowing sol (liquid) state due to enhanced hydration of the hydrophilic PEG blocks.When warmed to physiological body temperature (37°C), enhanced hydrophobic interactions between the terminal PLGA blocks prompt micellar aggregation and physical cross-linking, inducing a rapid transition into a solid, viscoelastic gel network.\u003c\/p\u003e\n\u003cp\u003eIts main applications in bioelectronics are: (1) \u003cstrong\u003eConformable Interfacial Bio-Adhesive (Tissue-Electrode Interfacing)\u003c\/strong\u003e: Rigid or semi-flexible electrode arrays often suffer from micro-motion and poor conformal contact with dynamic tissues like the brain, heart, or skeletal muscle. Applied as a liquid precursor that gels instantly at body temperature, PLGA-PEG-PLGA encapsulates the electrode footprint, filling microscopic tissue irregularities and dramatically reducing interfacial impedance. (2) \u003cstrong\u003eOn-Demand Injectable \/ Minimalist Implantation\u003c\/strong\u003e: For minimally invasive bioelectronics, the liquid formulation can be co-injected with micro-needle arrays or mesh electronics. It solidifies in situ to anchor the device securely without requiring extensive surgical suturing. (3) \u003cstrong\u003eControlled Localized Anti-Inflammatory Drug Delivery\u003c\/strong\u003e: The chronic foreign-body response and glial scar formation often degrade the signal-to-noise ratio of implanted bioelectronics. PLGA-PEG-PLGA hydrogels can be loaded with anti-inflammatory agents (such as dexamethasone) or growth factors, providing sustained, localized release as the polymer matrix undergoes bio-erosion and hydrolysis over weeks to months.\u003c\/p\u003e\n\u003ctable style=\"width: 100%; height: 293.087px;\" width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 35.6px;\"\u003e\n\u003ctd style=\"width: 32.9886%; height: 35.6px;\"\u003e\u003cem\u003ePart Number\u003c\/em\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 66.6904%; height: 35.6px;\"\u003e\n\u003cp\u003e\u003cspan\u003eCBETSPLGAHG (C-BE-TSPLGHG)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.6px;\"\u003e\n\u003ctd style=\"width: 32.9886%; height: 35.6px;\"\u003e\u003cem\u003eCAS\u003c\/em\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 66.6904%; height: 35.6px;\"\u003e\n\u003cp\u003e952111-10-3\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 77.4px;\"\u003e\n\u003ctd style=\"width: 32.9886%; height: 77.4px;\"\u003e\u003cem\u003eChemical Formula\/Structure\u003c\/em\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 66.6904%; height: 77.4px;\"\u003e\n\u003cdiv style=\"text-align: start;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0774\/6591\/1526\/files\/CBETSPLGAHG_Structure_240x240.jpg?v=1791908610\" style=\"margin-bottom: 16px; float: none;\"\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 108.6px;\"\u003e\n\u003ctd style=\"width: 32.9886%; height: 108.6px;\"\u003e\u003cem\u003eHydrogel Feature\u003c\/em\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 66.6904%; height: 108.6px;\"\u003e\n\u003cp\u003eWhen the environmental temperature below the phase change temperature, the copolymer can be dissolved in water to form free fluid liquid, while it will form gel when the environmental temperature is higher than the phase change point. \u003c\/p\u003e\n\u003cp\u003eThe whole process is reversible. \u003c\/p\u003e\n\u003cdiv style=\"text-align: start;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0774\/6591\/1526\/files\/CBETSPLGAHG_02_100x100.jpg?v=1791909751\" alt=\"\" style=\"float: none;\"\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.8875px;\"\u003e\n\u003ctd style=\"width: 32.9886%; height: 35.8875px;\"\u003e\u003cem\u003ePackage Size\u003c\/em\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 66.6904%; height: 35.8875px;\"\u003e10 g\/bottle\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eNotes\u003c\/strong\u003e: Please try to store the PLGA-PEG-PLGA hydrogel in a dry place. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eReferences\u003c\/strong\u003e: \u003c\/span\u003e\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003e\u003cspan\u003e\u003ca href=\"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/adma.202400181\"\u003eJ. Lin, et al. Wireless Bioelectronics for In Vivo Pressure Monitoring with Mechanically-Compliant Hydrogel Biointerfaces, Adv. Mater., 2024, 36, 2400181\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S095656632400602X\"\u003eQ. Zhang, et al. Multi-functional adhesive hydrogel as bio-interface for wireless transient pacemaker, Biosensors and Bioelectronics, 2024, 263, 116597\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"DGSW","offers":[{"title":"Default Title","offer_id":67705224593638,"sku":"CBETSPLGAHG","price":89.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0774\/6591\/1526\/files\/CBETSPLGAHG_main.jpg?v=1791908560","url":"https:\/\/echemsupplies.com\/products\/cbetsplgahg","provider":"EChem Supplies","version":"1.0","type":"link"}