HA-PBA (Phenylboronic Acid-functionalized Hyaluronic Acid) Powder for Responsive Hydrogel Synthesis, 1 g/bottle, CRHSHAPBA

HA-PBA (Phenylboronic Acid-functionalized Hyaluronic Acid) is a key polymer building block for creating smart, stimuli-responsive hydrogels. Because phenylboronic acid reversibly forms dynamic covalent ester bonds with cis-diol-containing molecules (such as sugars, polyvinyl alcohol, or catechol derivatives), HA-PBA hydrogels exhibit exceptional self-healing, injectability, and responsiveness to environments like glucose or reactive oxygen species (ROS).

Part Number	CRHSHAPBA (C-RHS-HAPBA)
Chemical Formula/Structure
Molecular Weight	Mw=100000 (other molecular weight of 50000 and 400000 also can be supplied upon request)
NMR
Hydrogel Preparation Steps	(1). 2% HA-PBA solution preparation: Weigh 0.02 g HA-PBA powder and dissolve it in 1 mL PBS under ultrasonic assistance for 1-4 h.  (2) 3% PVA solution preparation: Weigh 0.03 g PVA powder and dissolve it in 1 mL PBS. Heat it up to 50°C until the mixture becomes clear (1- 4 h). (3) Take 400 uL 2% HA-PBA solution and slowly add the 200 uL 3% PVA solution under stirring. The hydrogel will form under vibration.
Package Size	1 g/bottle

Notes: Please try to store the HA-PBA powder in a dry place. 

References: 

1. S. Y. Cheon, et al. Injectable and Self-Curing Single-Component Hydrogel for Stem Cell Encapsulation and In Vivo Bone Regeneration, Adv. Sci., 2024, 11, 2304861
2. W. Shi, et al. Fabrication of versatile dynamic hyaluronic acid-based hydrogels, Carbohydrate Polymers, 2020, 233, 115803