HAMA-PBA (Phenylboronic Acid-Modified Methacrylated Hyaluronic Acid) Powder for Responsive Hydrogel Synthesis, 0.5 g/bottle, CRHSHAMAPBA
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HAMA-PBA (Phenylboronic Acid-Modified Methacrylated Hyaluronic Acid) is an advanced, dual-crosslinkable biopolymer designed for sophisticated tissue engineering, 3D bioprinting, and responsive drug delivery systems. By combining both methacrylate groups (for rapid, permanent photo-crosslinking) and phenylboronic acid groups (for dynamic, stimuli-responsive, and self-healing covalent interactions), HAMA-PBA allows you to create hydrogels with tunable mechanical stiffness, shear-thinning injectability, and environmental responsiveness (to glucose, pH, or reactive oxygen species).
| Part Number |
CRHSHAMAPBA (C-RHS-HAMAPBA) |
| Chemical Formula/Structure |
 |
| Molecular Weight |
Mw=100000 (other molecular weight of 50000 also can be supplied upon request)
|
| NMR |
 |
| Hydrogel Preparation Steps |
(1). 0.25% (2.5 mg/mL) photoinitiator solution preparation: Add 20 mL PBS into the 0.05 g LAP brown bottle and heat it for 15 min at 40-50°C for complete dissolution. (2) 4% HAMA-PBA solution preparation: Weigh 0.4g HAMA-PBA powder and dissolve it in 1 mL PBS+LAP solution . Heat it up to 50°C until the mixture becomes clear (1- 4 h). (3) 3% PVA solution preparation: Weigh 0.03 g PVA powder and dissolve it in 1 mL PBS+LAP solution, and heat it at 50°C for 1-4 h until it becomes clear. (4) Hydrogel Formation: Take 200 uL 4% HAMA-PBA solution and mix with 100 uL 3% PVA solution and then add 5 uL 1 M NaOH to form gel. |
| Storage Conditions |
Store it at 2-8 °C (avoid light) for upto 7 days. |
| Package Size | 0.5 g/bottle |
Notes: Please try to store the HAMA-PBA powder in a dry & cold place.
References:
- Z. Xu, et al. Hyaluronic acid-based glucose-responsive antioxidant hydrogel platform for enhanced diabetic wound repair, Acta Biomaterialia, 2022, 147, 147-157
- Z. Lin, et al. Smart responsive injectable hydrogel loaded with icariin inhibits ferroptosis and promotes nucleus pulposus repair in intervertebral disc degeneration, Biomaterials Advances, 2026, 179, 214513